Lepore L, Agosti E, Pennesi M, Barbi E, De Manzini A
Clinica Pediatrica, Istituto per l'Infanzia Burlo Garofolo, Trieste, Italia.
Pediatr Med Chir. 1988 Mar-Apr;10(2):191-3.
A case of severe juvenile rheumatoid arthritis, polyarticular type, refractory to FANS and long acting therapy which showed a quick remission after measles is described. An immunosuppressive therapy to strengthen the immunosuppression induced by virus infection was performed for six months. The remission has been maintained for 4 years and appears up to now to be stable with no therapy. On the basis of this observation, the possibility of a vaccination therapy with measles virus, which equally gives immunosuppression, is discussed.
本文描述了一例严重的青少年类风湿关节炎，多关节型，对金制剂（FANS）和长效治疗无效，但在感染麻疹后迅速缓解。进行了为期六个月的免疫抑制治疗，以增强病毒感染诱导的免疫抑制作用。缓解状态已维持了4年，目前在未进行治疗的情况下似乎保持稳定。基于这一观察结果，讨论了使用同样具有免疫抑制作用的麻疹病毒进行疫苗治疗的可能性。
