N-(5-羟基烟酰基)-L-谷氨酸钙盐在啮齿动物实验中减轻抑郁样行为和帕金森综合征
Calcium Salt of N-(5-Hydroxynicotinoyl)-L-Glutamic Acid Weakens Depressive-Like Behavior and Parkinsonian Syndrome in Experiment on Rodents.
作者信息
Kiselev A V, Vedenkin A S, Stovbun I S, Sergienko V I, Kalinina T S
机构信息
N. N. Semenov Institute of Chemical Physics, Russian Academy of Science, Moscow, Russia.
V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2019 Nov;168(1):48-51. doi: 10.1007/s10517-019-04643-5. Epub 2019 Nov 19.
We studied antidepressant and antiparkinsonian properties of N-(5-hydroxynicotinoyl)-Lglutamic acid calcium salt (Ampasse) in rodents. It was found that Ampasse in a dose of 30 mg/kg exhibited antidepressant activity in the forced swimming test in mice and in a dose of 0.1 mg/kg maximally alleviates the symptoms of parkinsonian syndrome induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57Bl/6 mice, and haloperidol-induced catalepsy in rats.
我们研究了N-(5-羟基烟酰基)-L-谷氨酸钙盐（安帕西）在啮齿动物中的抗抑郁和抗帕金森病特性。结果发现，30mg/kg剂量的安帕西在小鼠强迫游泳试验中表现出抗抑郁活性，0.1mg/kg剂量的安帕西能最大程度缓解C57Bl/6小鼠全身注射1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的帕金森综合征症状，以及大鼠氟哌啶醇诱导的僵住症。
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