Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430014, China.
Sci China Life Sci. 2019 Dec;62(12):1580-1589. doi: 10.1007/s11427-018-9831-5. Epub 2019 Nov 18.
Rapid weight gain (RWG) in infants is associated with numerous health problems, and its risk factors are still unclear. We assessed 98,097 maternal-infant pairs from a population-based cohort study and followed up with them until the infants were 6 months old. We assessed the associations between maternal prepregnancy weight status; gestational weight gain; feeding pattern; and infants' RWG at 0-1, 0-3, 1-3, and 3-6 months using multivariate unconditional logistic regression models, with controlled confounders. We found that maternal prepregnancy weight status, gestational weight gain, and feeding pattern at the 1st, 3rd, and 6th months had significant impacts on the infants' RWG at each time period (P<0.05). Infants with overweight/obese mothers had a higher risk of RWG after birth, whereas those of mothers who experienced excessive gestational weight gain had higher risks of RWG from birth than the other groups (P<0.01). Infants who were formula-fed had a higher risk of RWG than breastfed infants at the same time point (P<0.01). In conclusion, maternal prepregnancy obesity, excessive gestational weight gain, and formula-feeding were risk factors for infants' RWG during the first 6 months of life.
婴儿体重快速增长（RWG）与许多健康问题有关，其危险因素仍不清楚。我们评估了一项基于人群的队列研究中的 98097 对母婴对，并对其进行了随访，直到婴儿 6 个月大。我们使用多变量非条件逻辑回归模型评估了母亲孕前体重状况；孕期体重增加；喂养模式；以及婴儿在 0-1、0-3、1-3 和 3-6 个月时的 RWG，同时控制了混杂因素。我们发现，母亲孕前体重状况、孕期体重增加和第 1、3、6 个月的喂养模式对每个时期婴儿的 RWG 都有显著影响（P<0.05）。超重/肥胖母亲的婴儿出生后 RWG 的风险更高，而体重过度增加的母亲的婴儿出生后 RWG 的风险高于其他组（P<0.01）。配方奶喂养的婴儿在同一时间点 RWG 的风险高于母乳喂养的婴儿（P<0.01）。总之，母亲孕前肥胖、孕期体重过度增加和配方奶喂养是婴儿生命前 6 个月 RWG 的危险因素。
