肾去神经支配：黑暗的过去，光明的未来？
Renal denervation: dark past, bright future?
作者信息
Heradien Marshall, Mahfoud Felix, Hettrick Doug, Brink Paul
机构信息
Department of Internal Medicine, Stellenbosch University, Cape Town, South Africa. Email:
Klinik für Innere Medizin III, Saarland University Hospital, Homburg, Saarland, Germany.
出版信息
Cardiovasc J Afr. 2019 Sep/Oct;30(5):290-296. doi: 10.5830/CVJA-2019-045.
Abstract
The purpose of this review is to update the reader on the relevance of autonomic nervous system imbalance in clinical cardiology. Increased sympathetic tone associates with the metabolic syndrome, hypertension and cardiac arrhythmias. With the kidneys playing a pivotal role in increased peripheral resistance, sodium and water retention and other mechanisms, renal denervation (RD) may theoretically restore autonomic imbalance and improve cardiovascular outcomes. Landmark RD trials and novel uses for RD in cardiac arrhythmia management are discussed.
摘要
本综述的目的是向读者介绍自主神经系统失衡在临床心脏病学中的相关性。交感神经张力增加与代谢综合征、高血压和心律失常相关。由于肾脏在增加外周阻力、钠水潴留及其他机制中起关键作用，肾去神经支配（RD）理论上可能恢复自主神经失衡并改善心血管结局。文中讨论了具有里程碑意义的RD试验以及RD在心律失常管理中的新用途。
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