Grant S J, Huang Y H, Redmond D E
Neurobehavior Laboratory, Yale University School of Medicine, New Haven, CT 06510.
Pharmacol Biochem Behav. 1988 May;30(1):13-9. doi: 10.1016/0091-3057(88)90419-4.
The noradrenergic nucleus locus coeruleus (LC) has been implicated in morphine withdrawal. The behavioral effects of opiate antagonist-precipitated morphine withdrawal in chair-restrained Macaca arctoides were therefore compared with LC electrical field stimulation. Both continuous LC stimulation and administration of low doses of naloxone to morphine pellet implanted monkeys produced a significant increase in the same group of behaviors reported previously to follow activation of the LC, without significant increases in general activity or distress behaviors. Signs of autonomic hyperactivity and distress were observed at high doses of naloxone, but not during LC stimulation. Monkeys which had not received morphine treatment did not specifically increased during low intensity LC stimulation is also selectively increased during naloxone-precipitated morphine withdrawal. These data are consistent with and suggest a behavioral consequence of the interactions of opioids with the LC reported at the molecular, intracellular, and cellular level.
去甲肾上腺素能蓝斑核（LC）与吗啡戒断有关。因此，将椅子束缚的熊猴中阿片拮抗剂诱发的吗啡戒断行为效应与LC电场刺激进行了比较。对植入吗啡丸的猴子进行持续的LC刺激和给予低剂量纳洛酮，都会使先前报道的在LC激活后出现的同一组行为显著增加，而一般活动或痛苦行为没有显著增加。高剂量纳洛酮时观察到自主神经功能亢进和痛苦的迹象，但在LC刺激期间未观察到。未接受吗啡治疗的猴子在低强度LC刺激期间没有特异性增加，在纳洛酮诱发的吗啡戒断期间也有选择性增加。这些数据与在分子、细胞内和细胞水平上报道的阿片类药物与LC相互作用的行为后果一致，并表明了这种行为后果。
