Warren D A, Rosellini R A
Department of Psychology, State University of New York, Albany 12222.
Pharmacol Biochem Behav. 1988 May;30(1):209-14. doi: 10.1016/0091-3057(88)90446-7.
Controllable shock is known to exert less deleterious effects than does the equivalent exposure to inescapable shock. Recent findings have encouraged speculation that some of these effects may result from differences in the severity of fear produced by the shock experiences. In particular, mediation by gamma-aminobutyric acid has been implicated. In the present experiment, we examined the possibility that chlordiazepoxide (CDP) would attenuate the impact of shock in a manner similar to that of providing control over shock. As shown by others, CDP administered prior to shock treatment blocked the long-term analgesic response, as did the provision of control during shock. Furthermore, whereas animals given controllable shock subsequently exhibited less fear of the shock context than did yoked animals, CDP treatment prior to uncontrollable shock did not appreciably reduce the contextual fear subsequently shown. These results suggest that under some conditions, controllability attenuates the impact of stress by mechanisms other than those shared by benzodiazepine treatment.
已知可控性电击比同等强度的不可逃避电击产生的有害影响更小。最近的研究结果引发了一种猜测，即其中一些影响可能源于电击经历所产生的恐惧程度差异。特别是，γ-氨基丁酸的介导作用已被牵连其中。在本实验中，我们研究了氯氮卓（CDP）是否会以类似于提供对电击的控制的方式减轻电击的影响。正如其他人所表明的那样，在电击治疗前给予CDP会阻断长期镇痛反应，电击期间提供控制也是如此。此外，接受可控性电击的动物随后对电击环境的恐惧比配对动物少，而在不可控电击前进行CDP治疗并没有明显降低随后表现出的环境恐惧。这些结果表明，在某些情况下，可控性通过不同于苯二氮卓类治疗所共有的机制来减轻应激的影响。
