苯环利定增强体内3H-东莨菪碱积累的参数研究。

Parametric studies on phencyclidine enhancement of 3H quinuclidinyl benzilate accumulation in vivo.

作者信息

Boggan W O, Faught K, Boyd S, Middaugh L D

机构信息

Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, Charleston 29425-0742.

出版信息

Pharmacol Biochem Behav. 1988 May;30(1):31-5. doi: 10.1016/0091-3057(88)90421-2.

DOI:10.1016/0091-3057(88)90421-2

PMID:3174753

Abstract

The purpose of these experiments was to define the temporal parameters involved in the phencyclidine (PCP) enhancement of 3H quinuclidinyl benzilate (QNB) accumulation in mouse brain. PCP enhanced QNB accumulation in brain if given intraperitoneally (IP) 1 and 4, but not 16 hours before intravenous (IV) administration of QNB. This effect was found in hypothalamus, striatum, cortex and hippocampus, but not cerebellum. PCP given after QNB did not alter QNB accumulation. The PCP enhancement persisted for at least 72 hours after QNB administration. These results confirm previous studies demonstrating that PCP must be present prior to QNB administration to enhance the accumulation and show that the effect persists for an extended period of time.

摘要

这些实验的目的是确定苯环利定（PCP）增强小鼠脑中3H-东莨菪碱（QNB）蓄积所涉及的时间参数。如果在静脉注射（IV）QNB前1小时和4小时腹腔注射（IP）PCP，PCP可增强脑中QNB的蓄积，但在静脉注射QNB前16小时腹腔注射PCP则无此作用。在下丘脑、纹状体、皮层和海马中发现了这种效应，但在小脑中未发现。在QNB给药后给予PCP不会改变QNB的蓄积。在QNB给药后，PCP的增强作用持续至少72小时。这些结果证实了先前的研究，即PCP必须在QNB给药之前存在才能增强蓄积，并表明这种效应会持续很长一段时间。