Stellar J R, Waraczynski M, Bruno J P
Department of Psychology, Harvard University, Cambridge, MA 02138.
Pharmacol Biochem Behav. 1988 Jun;30(2):365-70. doi: 10.1016/0091-3057(88)90469-8.
Previous research has shown that adult rats sustaining near-total depletions of striatal dopamine (DA) as neonates exhibit few of the profound deficits in ingestion and sensory-motor behavior seen in comparably lesioned adults. This study extends these findings to another realm of DA-related behavior, reward function. In a rate-frequency curve-shift measurement paradigm, reward effectiveness of lateral hypothalamic brain stimulation was shown to be normal in adult rats depleted of brain DA as neonates. However, impairments were seen in rapid-initiation operant performance. Neonatally DA-depleted rats were also shown to be subsensitive to the DA receptor antagonist pimozide, suggesting that activity within undamaged DA neurons is not necessary for the elicitation of hypothalamic self-stimulation reward.
先前的研究表明，新生期纹状体多巴胺（DA）几乎完全耗竭的成年大鼠，在摄食和感觉运动行为方面几乎没有出现与成年期同等损伤程度的大鼠所表现出的严重缺陷。本研究将这些发现扩展到DA相关行为的另一个领域，即奖赏功能。在频率曲线偏移测量范式中，结果显示，新生期脑DA耗竭的成年大鼠，下丘脑外侧脑刺激的奖赏效力正常。然而，在快速启动的操作性行为表现中出现了损伤。新生期DA耗竭的大鼠对DA受体拮抗剂匹莫齐特也表现出低敏感性，这表明未受损的DA神经元内的活动并非引发下丘脑自我刺激奖赏所必需。
