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在血管腔内修复时代,采用部分体外循环技术置换胸降主动脉瘤。

Replacement of the descending thoracic aortic aneurysm with partial cardiopulmonary bypass in the era of endovascular repair.

作者信息

Uehara Kyokun, Matsuda Hitoshi, Matsuo Jiro, Inoue Yosuke, Shijo Takayuki, Omura Atsushi, Seike Yoshimasa, Sasaki Hiroaki, Kobayashi Junjiro

机构信息

Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, 6-1 Kishibeshinmachi, Suita, Japan.

出版信息

Gen Thorac Cardiovasc Surg. 2020 Jun;68(6):596-603. doi: 10.1007/s11748-019-01253-w. Epub 2019 Nov 20.

Abstract

OBJECTIVES

Although the advent of thoracic endovascular aortic repair (TEVAR) has provided an alternative treatment option for descending thoracic aortic aneurysm (DTAA), open repair still plays a crucial role in DTAA repair. The purpose of this study was to re-evaluate the operative and long-term outcomes of open repair with partial cardiopulmonary bypass, compared to the results of TEVAR with a proximal landing zone of 3 or 4.

METHODS

Between 2007 and 2017, open repair was performed for 44 patients and TEVAR for 282 patients. Acute aortic dissection and open proximal anastomosis under circulatory arrest were excluded. Perioperative and long-term follow-up data were analyzed.

RESULTS

In-hospital mortality rate (4.5% vs 3.2%, p = 0.42), and frequencies of spinal cord injury and neurological deficit showed no significant differences between the open repair and TEVAR groups (p = 0.41, 0.25, respectively). The propensity score-matched analysis showed similar cumulative survival (p = 0.23), but significantly higher reintervention rates for the repaired segment in the TEVAR group than in the open repair group (p = 0.0054). Twenty-two (7.8%) TEVAR patients required re-interventions for the repaired segment. Of those, 17 patients underwent additional TEVAR and 5 patients needed open conversion surgery with partial cardiopulmonary bypass. Reintervention rates for the repaired segment were significantly higher in the TEVAR group than in the open repair group (p = 0.012).

CONCLUSIONS

Open repair DTAA using partial cardiopulmonary bypass showed operative outcomes comparable to TEVAR and lower reintervention rates, and thus remains an acceptable procedure for selected patients in this era of endovascular repair.

摘要

目的

尽管胸主动脉腔内修复术(TEVAR)的出现为降主动脉瘤(DTAA)提供了另一种治疗选择,但开放修复在DTAA修复中仍起着关键作用。本研究的目的是重新评估采用部分体外循环的开放修复术的手术及长期疗效,并与近端锚定区为3或4的TEVAR结果进行比较。

方法

2007年至2017年间,对44例患者进行了开放修复术,对282例患者进行了TEVAR。排除急性主动脉夹层和循环停滞下的开放近端吻合术。分析围手术期和长期随访数据。

结果

开放修复组和TEVAR组的住院死亡率(4.5%对3.2%,p = 0.42)、脊髓损伤和神经功能缺损发生率无显著差异(分别为p = 0.41、0.25)。倾向评分匹配分析显示累积生存率相似(p = 0.23),但TEVAR组修复节段的再次干预率显著高于开放修复组(p = 0.0054)。22例(7.8%)TEVAR患者需要对修复节段进行再次干预。其中,17例患者接受了额外的TEVAR,5例患者需要采用部分体外循环进行开放转换手术。TEVAR组修复节段的再次干预率显著高于开放修复组(p = 0.012)。

结论

采用部分体外循环的开放修复DTAA显示出与TEVAR相当的手术疗效且再次干预率更低,因此在这个血管腔内修复时代,对于选定的患者来说仍是一种可接受的手术方式。

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