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腮腺局部晚期肿瘤的颞骨外侧切除术评估

Evaluation of Lateral Temporal Bone Resection in Locally Advanced Tumours of the Parotid Gland.

作者信息

Aslıer Mustafa, Doğan Ersoy, İkiz Ahmet Ömer, Sarıoğlu Sülen, Akman Fadime, Güneri Enis Alpin

机构信息

1Department of Otorhinolaryngology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

Present Address: Sancaktepe Şehit Prof. Dr. İlhan Varank Education and Research Hospital, Emek Mahallesi, Namık Kemal Cad., Sancaktepe, 34785 İstanbul, Turkey.

出版信息

Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 2):1402-1407. doi: 10.1007/s12070-018-1483-4. Epub 2018 Aug 30.

DOI:10.1007/s12070-018-1483-4
PMID:31750185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6841771/
Abstract

This study evaluated the effects of lateral temporal bone resection (LTBR) on local tumour control in patients with locally advanced parotid gland tumours. The medical records of seven patients treated with radical parotidectomy combined with LTBR for locally advanced primary parotid tumour at the Otolaryngology Department of Dokuz Eylul University between January 1995 and December 2016 were retrospectively evaluated. Demographic variables, tumour characteristics, treatment properties, postoperative complications, follow-up durations and local, regional and distant recurrences were analysed. Before referral to our clinic, four patients had primary parotid tumours, and three patients had a recurrence of primary parotid tumours. The histopathologic diagnoses were squamous cell carcinoma in two patients, and adenosquamous carcinoma, malignant myoepithelial carcinoma, adenocarcinoma, adenoid cystic carcinoma and spindle cell sarcoma in the other patients. During the follow-up period, one patient died due to postoperative pulmonary embolism in the first month, and four patients died due to distant metastasis without local or regional recurrences. LTBR combined with radical parotidectomy in locally advanced primary malignant parotid gland tumours is a feasible surgical technique for local tumour control. However, the most common cause of death in these cases is distant metastases, despite appropriate resection.

摘要

本研究评估了颞骨外侧切除术(LTBR)对局部晚期腮腺肿瘤患者局部肿瘤控制的效果。回顾性分析了1995年1月至2016年12月期间在多库兹艾吕尔大学耳鼻喉科接受根治性腮腺切除术联合LTBR治疗局部晚期原发性腮腺肿瘤的7例患者的病历。分析了人口统计学变量、肿瘤特征、治疗特性、术后并发症、随访时间以及局部、区域和远处复发情况。在转诊至我们诊所之前,4例患者患有原发性腮腺肿瘤,3例患者为原发性腮腺肿瘤复发。组织病理学诊断为2例鳞状细胞癌,其余患者分别为腺鳞癌、恶性肌上皮癌、腺癌、腺样囊性癌和梭形细胞肉瘤。在随访期间,1例患者在术后第一个月因肺栓塞死亡,4例患者因远处转移死亡,无局部或区域复发。对于局部晚期原发性恶性腮腺肿瘤,LTBR联合根治性腮腺切除术是一种可行的局部肿瘤控制手术技术。然而,尽管进行了适当的切除,但这些病例最常见的死亡原因是远处转移。