Huang Tung-Tsun, Chou Yu-Fu, Wen Yu-Hsuan, Chen Peir-Rong
Department of Otolaryngology, Taipei Tzu Chi Hospital, Taipei, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan.
School of Medicine, Tzu Chi University, Hualien, Taiwan; Department of Otolaryngology, Hualien Tzu Chi Hospital, Hualien, Taiwan.
Br J Oral Maxillofac Surg. 2016 Jul;54(6):625-8. doi: 10.1016/j.bjoms.2016.03.014. Epub 2016 Apr 6.
Sublingual gland tumours are rare, and we have evaluated the clinical features and prognosis of patients treated at a tertiary medical centre in eastern Taiwan. We retrospectively reviewed the cases of nine patients with sublingual gland tumours that were resected from December 1993 to November 2008, four of whom were men and five women. The median (range) age at diagnosis was 52 (39-63) years. Seven had malignant tumours, of which adenoid cystic carcinoma was the most common. All patients with malignant tumours had neck dissections, and four had cervical lymph node metastases. The incidence of lymph node metastases was much higher in patients with advanced primary tumours (T1/2 compared with T3/4: one out of three compared with three out of four). All patients with malignant tumours were given adjuvant radiotherapy. There were no local failures. One patient had regional recurrence in the neck and had a successful further resection. Three patients developed distant metastases, and two died during the follow-up period. Our results suggest that radical resection with postoperative radiotherapy offers adequate local and regional control for malignant sublingual gland tumours. Neck dissection is beneficial, especially for T3/4 disease.
舌下腺肿瘤较为罕见，我们评估了在台湾东部一家三级医疗中心接受治疗的患者的临床特征及预后。我们回顾性分析了1993年12月至2008年11月期间切除的9例舌下腺肿瘤患者的病例，其中4例为男性，5例为女性。诊断时的中位（范围）年龄为52（39 - 63）岁。7例为恶性肿瘤，其中腺样囊性癌最为常见。所有恶性肿瘤患者均接受了颈部清扫术，4例有颈部淋巴结转移。晚期原发性肿瘤患者的淋巴结转移发生率要高得多（T1/2与T3/4相比：三分之一与四分之三）。所有恶性肿瘤患者均接受了辅助放疗。无局部复发。1例患者颈部出现区域复发，再次成功切除。3例患者发生远处转移，2例在随访期间死亡。我们的结果表明，根治性切除加术后放疗可为恶性舌下腺肿瘤提供充分的局部和区域控制。颈部清扫术有益，尤其是对于T3/4期疾病。
