Muneeb Altif, Dhamoon Amit S.
SUNY Upstate Medical University
Pulmonary embolism (PE) secondary to venous thromboembolism (VTE) is a major preventable cause of mortality in hospitalized patients. Prophylactic anticoagulation with mechanical and pharmacological therapies is indicated for high-risk patients. Pharmacological anticoagulation is the first-line treatment for newly diagnosed VTE and pulmonary embolism. Inferior vena cava (IVC) filter is a treatment option to prevent pulmonary embolism in a select group of patients that have venous thromboembolism (VTE) and absolute contraindication to anticoagulation, failure of anticoagulation, complications resulting from anticoagulation or progression of deep vein thrombosis (DVT) despite adequate anticoagulation. The Greenfield inferior vena cava filter came on the market in 1973. Currently, there are two categories of IVC filters in use: permanent and retrievable. The use of IVC filters has increased since the advent of retrievable IVC filters that were approved by the FDA in 2003 and 2004. Most studies have not shown any difference in the all-cause mortality in deep venous thrombosis (DVT) patients treated with IVC filters compared to the ones treated with anticoagulation therapy alone. Prophylactic IVC filters are sometimes inserted in patients at high risk of developing venous thromboembolism (VTE), especially if there is a contraindication to anticoagulation. These studies have not shown any mortality benefit. In fact, IVC filters correlate with an increased risk of recurrent deep vein thrombosis and other complications.
静脉血栓栓塞(VTE)继发的肺栓塞(PE)是住院患者主要的可预防死亡原因。对于高危患者,建议采用机械和药物疗法进行预防性抗凝。药物抗凝是新诊断的VTE和肺栓塞的一线治疗方法。下腔静脉(IVC)滤器是一种治疗选择,用于预防特定组患有静脉血栓栓塞(VTE)且对抗凝有绝对禁忌症、抗凝失败、抗凝引起的并发症或尽管进行了充分抗凝但仍发生深静脉血栓形成(DVT)进展的患者发生肺栓塞。格林菲尔德下腔静脉滤器于1973年上市。目前,正在使用的IVC滤器有两类:永久性和可回收性。自2003年和2004年美国食品药品监督管理局(FDA)批准可回收IVC滤器以来,其使用量有所增加。大多数研究表明,与仅接受抗凝治疗的患者相比,接受IVC滤器治疗的深静脉血栓形成(DVT)患者的全因死亡率没有差异。预防性IVC滤器有时会插入有发生静脉血栓栓塞(VTE)高风险的患者体内,特别是在存在抗凝禁忌症的情况下。这些研究并未显示出任何死亡率益处。事实上,IVC滤器与复发性深静脉血栓形成和其他并发症的风险增加相关。