KIR2DS4、KIR2DL2 和 KIR2DS4del 与头颈部鳞状细胞癌的基底样肿瘤、淋巴结转移、晚期和转移风险相关。
KIR2DS4, KIR2DL2, and KIR2DS4del are linked with basaloid tumors, lymph node metastasis, advanced stage and metastatic risk in head and neck squamous cell carcinoma.
机构信息
Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Iran; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Iran.
Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Iran.
出版信息
Exp Mol Pathol. 2020 Feb;112:104345. doi: 10.1016/j.yexmp.2019.104345. Epub 2019 Nov 18.
BACKGROUNDS
Our previous study has suggested that KIR2DS1, 2DS5, 3DS1 and KIR2DL5 are associated with head and neck squamous cell carcinoma (HNSCC) development. The purpose of the current study was to investigate the possible association of killer cell immunoglobulin like receptors (KIRs) gene with the clinicopathological features of patients.
METHODS
We reviewed the pathological reports of 285 pathologically confirmed cases of HNSCC and analyzed the association of KIR system with pathological characteristics.
RESULTS
A significant increase was demonstrated in the carrier frequency of KIR2DS4 in conventional than basaloid type and a higher frequency of lymph node metastasis (LNM) in carriers of KIR2DL2 and individuals possess 5 inhibitory KIRs (iKIRs). We also observed a higher proportion of patients with advanced stage of HNSCC in carriers of KIR2DL2 and deleted variant of KIR2DS4.
CONCLUSION
In HNSCC, KIR2DL2 is positively while KIR2DS4 is negatively associated with advanced stage. The higher proportion of LNM in carriers of KIR2DL2 and carriers of 5 iKIRs, suggested that inhibitory KIRs are associated with metastatic risk.
背景
我们之前的研究表明，KIR2DS1、2DS5、3DS1 和 KIR2DL5 与头颈部鳞状细胞癌（HNSCC）的发展有关。本研究的目的是探讨杀伤细胞免疫球蛋白样受体（KIR）基因与患者临床病理特征的可能关联。
方法
我们复习了 285 例经病理证实的 HNSCC 患者的病理报告，并分析了 KIR 系统与病理特征的关系。
结果
在经典型而非基底细胞型中，KIR2DS4 的携带频率显著增加，而 KIR2DL2 的携带者和具有 5 种抑制性 KIR（iKIR）的个体中淋巴结转移（LNM）的频率更高。我们还观察到，KIR2DL2 和 KIR2DS4 缺失变异体的携带者中，HNSCC 晚期患者的比例更高。
结论
在 HNSCC 中，KIR2DL2 与晚期呈正相关，而 KIR2DS4 与晚期呈负相关。KIR2DL2 携带者和 5 种 iKIR 携带者的 LNM 比例更高，提示抑制性 KIR 与转移风险相关。
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