Adamowicz Piotr, Jurczyk Agnieszka, Gil Dominika, Szustowski Szymon
Institute of Forensic Research, Westerplatte 9, 31-033 Krakow, Poland.
Department of Forensic Medicine, Medical University of Lodz, Sedziowska 18a, 91-304 Lodz, Poland.
Leg Med (Tokyo). 2020 Feb;42:101626. doi: 10.1016/j.legalmed.2019.101626. Epub 2019 Nov 12.
Cathinones are currently the second largest and the second most frequently seized group of new psychoactive substances (NPS). One of the most recent synthetic cathinones that has appeared on the 'legal highs' market is alpha-pyrrolidinoisohexanophenone (α-PiHP).
An 18-year-old man was found dead in an apartment. The autopsy materials were collected for toxicological analyses.
The quantitative analyses were carried out by LC-MS/MS.
α-PiHP was detected and quantified in all post-mortem materials except the hair. The determined concentrations of the compound in the blood, urine and bile were 69 ng/mL, 2072 ng/mL, and 341 ng/mL respectively. The concentrations of α-PiHP in solid tissues were in the range of 7-478 ng/g. 4-Chloromethcathinone (4-CMC), N-ethylhexedrone, benzoylecgonine and 3,4-methylenedioxymethamphetamine (MDMA) were also detected in some materials.
No cases presenting concentrations of α-PiHP in biological materials have been reported so far. Due to the similarity of structures and the reported dosages, an attempt to compare the concentrations of α-PVP and α-PHP has been made. In the described case, functional death through intoxication of α-PiHP was accepted as the final cause of death. The other detected substances did not contribute to death due to their very likely distant administration.
α-PiHP is another new synthetic cathinone that is a danger to the life of users. The described fatal intoxication case presents the concentrations of α-PiHP in post-mortem materials. This data could be valuable for further interpretation of other results from toxicological analyses in cases where the use of α-PiHP is suspected.
卡西酮类目前是新型精神活性物质（NPS）中被查获数量第二多、频率第二高的类别。出现在“合法兴奋剂”市场上的最新合成卡西酮之一是α-吡咯烷基异己苯酮（α-PiHP）。
一名18岁男子被发现死于一间公寓。收集尸检材料进行毒理学分析。
采用液相色谱-串联质谱法进行定量分析。
除毛发外，在所有尸检材料中均检测到并定量了α-PiHP。该化合物在血液、尿液和胆汁中的测定浓度分别为69纳克/毫升、2072纳克/毫升和341纳克/毫升。α-PiHP在固体组织中的浓度范围为7-478纳克/克。在一些材料中还检测到了4-氯甲基卡西酮（4-CMC）、N-乙基己酮、苯甲酰芽子碱和3,4-亚甲基二氧甲基苯丙胺（摇头丸）。
目前尚未有报告生物材料中α-PiHP浓度的病例。由于结构相似且有报道的剂量，已尝试比较α-PVP和α-PHP的浓度。在所描述的病例中，α-PiHP中毒导致的功能性死亡被认定为最终死因。其他检测到的物质由于很可能是在死亡时间较远之前摄入的，因此对死亡没有影响。
α-PiHP是另一种对使用者生命构成危险的新型合成卡西酮。所描述的致命中毒病例展示了α-PiHP在尸检材料中的浓度。这些数据对于怀疑使用α-PiHP的病例中毒理学分析的其他结果的进一步解读可能具有价值。
