Watanabe Shinichiro, Kawano Takashi, Horino Taro, Matsumoto Tatsuki, Nagata Keitaro, Hatakeyama Yutaka, Locatelli Fabricio M, Yokoyama Masataka, Terada Yoshio, Okuhara Yoshiyasu
Center for Innovative and Translational Medicine, Kochi Medical School, Kochi University, Nankoku, Japan.
Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan.
BMC Res Notes. 2019 Nov 21;12(1):756. doi: 10.1186/s13104-019-4783-1.
Hyperuricemia has been reported to be associated with the development of postoperative acute kidney injury (pAKI). However, it remains underdetermined whether hyperuricemia treatment could decrease the potential risk of pAKI. Here, we investigated this hypothesis among hyperuricemia patients with previously normal renal function by performing a retrospective database analysis.
The study screened 18,169 patients, and were examined preoperative serum creatinine, uric acid, and postoperative serum creatinine. Eight hundred thirty-six patients were finally analyzed for the study, of whom 232 were in the treatment group and 604 were in the non-treatment control group. After adjustment for multi-covariates including baseline (pre-treatment) serum uric acid (SUA) levels, the incidence of pAKI in the treatment group (9.05%; 95% CI 6.04-12.1%) was significantly lower than that in the control group (14.2%; 95% CI 11.2-17.2%). On the other hand, further adjusting for preoperative SUA levels, there was no significant difference in the expected incidence of pAKI between the groups.
据报道，高尿酸血症与术后急性肾损伤（pAKI）的发生有关。然而，高尿酸血症治疗是否能降低pAKI的潜在风险仍不明确。在此，我们通过进行回顾性数据库分析，在肾功能先前正常的高尿酸血症患者中研究了这一假设。
该研究筛选了18169例患者，并检测了术前血清肌酐、尿酸和术后血清肌酐。最终对836例患者进行了研究分析，其中232例在治疗组，604例在非治疗对照组。在对包括基线（治疗前）血清尿酸（SUA）水平在内的多个协变量进行调整后，治疗组pAKI的发生率（9.05%；95%CI 6.04-12.1%）显著低于对照组（14.2%；95%CI 11.2-17.2%）。另一方面，在进一步对术前SUA水平进行调整后，两组之间pAKI的预期发生率没有显著差异。
