Olschewski M, Verres R, Scheurlen H, Rauschecker H
Institut für Medizinische Biometrie und Informatik, Universität Freiburg, FRG.
Recent Results Cancer Res. 1988;111:258-69. doi: 10.1007/978-3-642-83419-6_29.
Our preliminary and exploratory data analysis of the current state of QOL assessment in the ongoing BMFT breast preservation trial indicates that our questionnaire meets criteria of validity, differentiability, and practicability in the context of a large multi-center trial. The results of treatment comparisons tend towards accordance with those of comparable studies, in that they do not show the often-postulated global superiority of breast-preserving therapy over mastectomy with respect to QOL. The special study concept of combining patients with and without treatment preference gives rise to a lot of methodological issues but is the only way to find out whether participation in the therapeutic decision-making process is beneficial to the patient or not.
我们对正在进行的BMFT保乳试验中生活质量评估现状进行的初步探索性数据分析表明，在大型多中心试验的背景下，我们的问卷符合有效性、区分性和实用性标准。治疗比较结果倾向于与同类研究结果一致，即在生活质量方面，保乳治疗并不显示出常被假定的相对于乳房切除术的总体优越性。将有和没有治疗偏好的患者相结合的特殊研究概念引发了许多方法学问题，但这是弄清楚参与治疗决策过程是否对患者有益的唯一途径。
