用钙调蛋白抑制剂硫利达嗪、丙咪嗪或氯丙嗪处理的对照大鼠和四氯化碳中毒大鼠肝脏中的谷胱甘肽（GSH）含量。

Glutathione (GSH) content in livers from control and carbon tetrachloride poisoned rats treated with the calmodulin inhibitors thioridazine, imipramine or chlorpromazine.

作者信息

Villarruel M C, de Ferreyra E C, Bernacchi A S, Castro J A

机构信息

Centro de Investigaciones Toxicológicas, CITEFA/CONICET, Bs. As., Argentina.

出版信息

Res Commun Chem Pathol Pharmacol. 1988 Jun;60(3):397-400.

PMID:3175337

Abstract

Administration to rats of the calmodulin (CaM) inhibitors Thioridazine (TDZ) or Imipramine (IMP) (50 mg/kg ip) or Chlorpromazine (CPZ) at a dose of 25 mg/kg, ip 6 hr after olive oil or CCl4 (1 ml/kg, ip as a 20% olive oil solution) significantly increased the GSH content in liver of CCl4 poisoned animals but not in controls. The analysis of present observations and past results with Trifluoperazine, suggest that increases in GSH content in CCl4 poisoned animals treated with protective anticalmodulins are a consequence of prevention and not the cause of their preventive effects.

摘要

给大鼠腹腔注射钙调蛋白（CaM）抑制剂硫利达嗪（TDZ）或丙咪嗪（IMP）（50毫克/千克），或在给予橄榄油或四氯化碳（1毫升/千克，以20%橄榄油溶液腹腔注射）6小时后腹腔注射25毫克/千克剂量的氯丙嗪（CPZ），显著增加了四氯化碳中毒动物肝脏中的谷胱甘肽（GSH）含量，但对照组未增加。对目前观察结果和过去使用三氟拉嗪的结果进行分析表明，用保护性抗钙调蛋白治疗的四氯化碳中毒动物体内GSH含量的增加是预防的结果，而非其预防作用的原因。