几种抗钙调蛋白药物对氨基半乳糖诱导的肝坏死的晚期预防作用。
Late preventive effects of several anticalmodulin drugs on galactosamine-induced liver necrosis.
作者信息
de Ferreyra E C, de Fenos O M, Castro J A
出版信息
Res Commun Chem Pathol Pharmacol. 1985 Feb;47(2):289-92.
PMID:3992011
Abstract
Four anticalmodulin drugs: trifluoperazine (TFP), pimozide (PMZ), thioridazine (TDZ) and imipramine (IMP) (50 mg/kg, ip) were able to partially prevent Galactosamine (GAL) (600 mg/kg, ip) induced liver necrosis when given 6 h after the hepatotoxin. IMP was also effective 10 h after GAL. The possibility of calmodulin participation in late stages of GAL-induced liver injury is analyzed.
摘要
四种抗钙调蛋白药物
三氟拉嗪（TFP）、匹莫齐特（PMZ）、硫利达嗪（TDZ）和丙咪嗪（IMP）（50毫克/千克，腹腔注射）在肝毒素给药6小时后给予时，能够部分预防半乳糖胺（GAL）（600毫克/千克，腹腔注射）诱导的肝坏死。IMP在GAL给药10小时后也有效。分析了钙调蛋白参与GAL诱导的肝损伤后期阶段的可能性。
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