Gadani Sachin P, Nadgir Rohini, Windon Annika, Rooper Lisa, Alghanim Fahid
Neurology, Johns Hopkins Hospital, Baltimore, USA.
Radiology, Johns Hopkins Hospital, Baltimore, USA.
Cureus. 2019 Oct 2;11(10):e5823. doi: 10.7759/cureus.5823.
A pituitary mass is a rare and poorly understood complication of granulomatosis with polyangiitis (GPA). Here we describe the case of a young woman with GPA who presented with signs and symptoms initially suggestive of meningitis but was ultimately found to have hypopituitarism and an enlarging sellar mass. She underwent transsphenoidal biopsy, which revealed an abundance of sterile inflammation and necrosis consistent with GPA-related inflammation. This case demonstrates a rare complication of GPA, i.e., a pituitary mass, initially mimicking meningitis. GPA-related pituitary involvement has an unknown pathogenesis and can have debilitating long-term consequences including chronic hypopituitarism and vision impairment, highlighting the need for further research.
垂体肿块是肉芽肿性多血管炎（GPA）一种罕见且了解甚少的并发症。在此，我们描述了一名患有GPA的年轻女性病例，她最初出现的症状和体征提示为脑膜炎，但最终发现患有垂体功能减退和蝶鞍肿块增大。她接受了经蝶窦活检，结果显示存在大量与GPA相关炎症相符的无菌性炎症和坏死。该病例展示了GPA一种罕见的并发症，即垂体肿块，最初类似脑膜炎。GPA相关的垂体受累发病机制不明，可导致包括慢性垂体功能减退和视力损害在内的长期衰弱后果，凸显了进一步研究的必要性。
