School of Public Health, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
Department of Pediatrics, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia, USA.
J Dig Dis. 2020 Jan;21(1):12-19. doi: 10.1111/1751-2980.12832.
The cost of treating the rare eosinophilic esophagitis (EoE) disease and its impact on patients' quality of life have not been well documented in the literature. This study seeks to fill this gap by comparing the cost of EoE with other well-known inflammatory diseases, including Crohn's disease (CD) and celiac disease (CeD).
A Mann-Whitney U test and multiple logistic regression were used to examine the cost of EoE in the state of Nevada across all hospital settings and its impact on quality of life compared with CD and CeD.
Several factors were associated with the overall cost of EoE in Nevada, including patients' age, sex and region (P < 0.001). EoE was significantly more expensive to treat in the pediatric group ($4001 EoE; $985 CD; $856 CeD), among men ($2532 EoE; $1500 CD; $1724 CeD), among those residing in the southern region of Nevada ($4501 EoE; $2538 CD; $1888 CeD), and among patients seeking medical care from outpatient clinics ($3298 EoE; $741 CD; $1686 CeD) (P < 0.001). Age, sex, region and hospital setting were all associated with having a positive EoE record compared with CeD or CD (P < 0.001).
Data from this study indicate that the EoE burden is significantly higher in cost for certain demographics and regions compared with CD and CeD in the state of Nevada, specifically among pediatric and male patients. These differences suggest that clinicians may encounter similar issues when treating EoE.
嗜酸细胞性食管炎（EoE）这种罕见疾病的治疗费用及其对患者生活质量的影响在文献中尚未得到充分记录。本研究旨在通过将 EoE 的成本与其他知名炎症性疾病（包括克罗恩病（CD）和乳糜泻（CeD））进行比较，来填补这一空白。
采用曼-惠特尼 U 检验和多元逻辑回归分析，考察内华达州所有医院环境下 EoE 的成本，并与 CD 和 CeD 进行比较，分析其对生活质量的影响。
有几个因素与内华达州 EoE 的总体成本相关，包括患者的年龄、性别和地区（P<0.001）。在儿科人群中，EoE 的治疗费用明显更高（EoE 为 4001 美元；CD 为 985 美元；CeD 为 856 美元），男性患者（EoE 为 2532 美元；CD 为 1500 美元；CeD 为 1724 美元），内华达州南部地区的患者（EoE 为 4501 美元；CD 为 2538 美元；CeD 为 1888 美元），以及在门诊接受治疗的患者（EoE 为 3298 美元；CD 为 741 美元；CeD 为 1686 美元）（P<0.001）。年龄、性别、地区和医院环境均与与 CeD 或 CD 相比，EoE 记录呈阳性相关（P<0.001）。
本研究数据表明，与内华达州的 CD 和 CeD 相比，EoE 在某些人群和地区的成本负担明显更高，特别是在儿科和男性患者中。这些差异表明，临床医生在治疗 EoE 时可能会遇到类似的问题。
