克莱斯托钙调素 A 和 B，来自. 的抗病毒间苯三酚萜类加合物
Cleistocaltones A and B, Antiviral Phloroglucinol-Terpenoid Adducts from .
机构信息
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , People's Republic of China.
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research , Jinan University , Guangzhou 510632 , People's Republic of China.
出版信息
Org Lett. 2019 Dec 6;21(23):9579-9583. doi: 10.1021/acs.orglett.9b03743. Epub 2019 Nov 22.
Two novel phloroglucinol-terpenoid adducts ( and ), featuring a rare 2,2,4-trimethyl-cinnamyl-β-triketone unit, were isolated from the buds of . Their structures with absolute configurations were established by spectroscopic analyses, single-crystal X-ray diffraction, and quantum chemical calculations. Structurally, compound represents a new carbon skeleton possessing a densely functionalized tricyclo[11.3.1.0]heptadecane bridged ring system with an unusual bridgehead enol. Compounds and exhibited significant antiviral activities against respiratory syncytial virus (RSV).
从 中芽中分离得到两个新的苯三酚萜类加合物（和），具有罕见的 2,2,4-三甲基肉桂基-β-三酮单元。通过光谱分析、单晶 X 射线衍射和量子化学计算确定了它们的结构和绝对构型。化合物 代表了一种新的碳骨架，具有一个高度官能化的三环[11.3.1.0]十七烷桥环系统和一个不寻常的桥头烯醇。化合物 和 对呼吸道合胞病毒（RSV）表现出显著的抗病毒活性。
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