来自硬枝红千层的抗病毒三酮-间苯三酚-单萜加合物。
Antiviral Triketone-Phloroglucinol-Monoterpene Adducts from Callistemon rigidus.
作者信息
Cao Jia-Qing, Wu Yan, Zhong Yuan-Lin, Li Ni-Ping, Chen Mu, Li Man-Mei, Ye Wen-Cai, Wang Lei
机构信息
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, P. R. China.
出版信息
Chem Biodivers. 2018 Jul;15(7):e1800172. doi: 10.1002/cbdv.201800172. Epub 2018 Jun 21.
Callistrilones F - K (1 - 6), six new triketone-phloroglucinol-monoterpene hybrids were isolated from the twigs and leaves of Callistemon rigidus. Their structures with absolute configurations were established by a combination analysis of NMR spectra, X-ray diffraction, and electronic circular dichroism (ECD) calculations. Compounds 3 and 4 exhibited moderate inhibitory activities against herpes simplex virus (HSV-1) with IC values of 10.00 ± 2.50 and 12.50 ± 1.30 μm, respectively.
从硬枝红千层的嫩枝和叶子中分离出了卡里斯特里酮F - K（1 - 6），六种新的三酮-间苯三酚-单萜杂合物。通过核磁共振光谱、X射线衍射和电子圆二色性（ECD）计算的组合分析确定了它们具有绝对构型的结构。化合物3和4对单纯疱疹病毒（HSV-1）表现出中等抑制活性，IC值分别为10.00±2.50和12.50±1.30μm。
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