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口腔阿片类药物用于接受临终关怀的患有危及生命疾病的儿童的爆发性疼痛。

Buccal opioids for breakthrough pain in children with life-limiting conditions receiving end-of-life care.

作者信息

Norman Cheryl, Maynard Linda

机构信息

Matron, East Anglia's Children's Hospices.

Consultant Nurse, Children's Palliative Care East Anglia's Children's Hospices.

出版信息

Int J Palliat Nurs. 2019 Oct 2;25(10):472-479. doi: 10.12968/ijpn.2019.25.10.472.

Abstract

BACKGROUND

Many palliative care health settings that care for children and young people (CYP) at the end of life use the buccal mucosa as a route of drug administration to manage the sudden onset of symptoms, such as seizures, agitation and dyspnoea, and for breakthrough pain management. The buccal route is a minimally invasive method that delivers fast symptom relief and is useful for those with swallowing impairment or reduced enteral absorption.

AIM

This paper reports on a small retrospective study involving 26 CYP who received end-of-life care between January and December 2017 to review the advantages and disadvantages of using buccal opioids for breakthrough pain relief with a focus on diamorphine as the preferred opioid.

METHOD

A retrospective case note review.

FINDINGS

This paper shares the clinical practice experiences from one UK organisation of care for CYP at the end of their lives and contributes to the growing body of pharmacological evidence.

CONCLUSION

Buccal opioids, specifically buccal diamorphine, are an effective strategy to treat breakthrough pain or dyspnoea in CYP.

摘要

背景

许多为临终儿童和青少年(CYP)提供护理的姑息治疗医疗机构将颊黏膜作为给药途径,以应对症状的突然发作,如癫痫发作、烦躁不安和呼吸困难,以及用于突破性疼痛管理。颊黏膜给药途径是一种微创方法,能快速缓解症状,对吞咽功能受损或肠内吸收减少的患者很有用。

目的

本文报告一项小型回顾性研究,该研究涉及26名在2017年1月至12月期间接受临终护理的CYP,以评估使用颊部阿片类药物缓解突破性疼痛的优缺点,重点关注二醋吗啡作为首选阿片类药物。

方法

回顾性病例记录审查。

研究结果

本文分享了英国一个为临终CYP提供护理的组织的临床实践经验,并为不断增加的药理学证据做出了贡献。

结论

颊部阿片类药物,特别是颊部二醋吗啡,是治疗CYP突破性疼痛或呼吸困难的有效策略。

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