Kondrakiewicz Kacper, Rokosz-Andraka Karolina, Nikolaev Tomasz, Górkiewicz Tomasz, Danielewski Konrad, Gruszczyńska Agata, Meyza Ksenia, Knapska Ewelina
Neurobiology of Emotions Laboratory, Centre of Excellence for Neural Plasticity and Brain Disorders (BRAINCITY), Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland.
Curr Protoc Neurosci. 2019 Dec;90(1):e85. doi: 10.1002/cpns.85.
Social transfer of fear is a potent tool facilitating response to danger in animals forming social groups. With many factors influencing the transfer-such as proximity of the animal receiving information to the donor, familiarity, proximity of danger, and species-specific coping strategies-it allows studies of neuronal correlates of a variety of behavioral responses. Since both the transfer of fear and social modulation of fear responses are impaired in many neuropsychological disorders, the models described in this article could be useful in disentangling the neuronal circuitry involved in the pathogenesis of these disorders. © 2019 by John Wiley & Sons, Inc. Basic Protocol 1: Imminent threat in rats Alternate Protocol 1: Imminent threat in mice Basic Protocol 2: Remote threat in rats Alternate Protocol 2: Remote threat in mice Basic Protocol 3: Social modulation of fear extinction in rats Alternate Protocol 3: Social modulation of fear extinction in mice.
恐惧的社会传递是一种强大的工具，有助于形成社会群体的动物对危险做出反应。由于有许多因素影响这种传递，比如接收信息的动物与供体的接近程度、熟悉程度、危险的接近程度以及物种特有的应对策略，它使得对各种行为反应的神经元相关性进行研究成为可能。由于在许多神经心理障碍中，恐惧传递和恐惧反应的社会调节均受到损害，本文所描述的模型可能有助于厘清这些障碍发病机制中涉及的神经回路。© 2019 约翰威立国际出版公司。基本方案 1：大鼠的迫在眉睫的威胁 替代方案 1：小鼠的迫在眉睫的威胁 基本方案 2：大鼠的远程威胁 替代方案 2：小鼠的远程威胁 基本方案 3：大鼠恐惧消退的社会调节 替代方案 3：小鼠恐惧消退的社会调节。
