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滤泡性胰腺炎:一种罕见的胰腺炎性假瘤。

Follicular pancreatitis: A rare pancreatic inflammatory pseudotumor.

机构信息

Department of Radiology, University of California San Diego, San Diego, CA, USA.

Department of Pathology, University of California San Diego, San Diego, CA, USA; Department of Pathology, VA San Diego Healthcare System, San Diego, CA, USA.

出版信息

Clin Imaging. 2020 Jan;59(1):39-44. doi: 10.1016/j.clinimag.2019.08.006. Epub 2019 Oct 25.

DOI:10.1016/j.clinimag.2019.08.006
PMID:31756593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6938461/
Abstract

Inflammatory pseudotumors imitate neoplasms on imaging but actually represent focal inflammation. We report a case of follicular pancreatitis, which is a recently recognized distinct form of mass-forming focal chronic pancreatitis pathologically characterized by lymphoid infiltration with abundant reactive germinal centers. In our patient, follicular pancreatitis manifested as a pancreatic tail mass that was resected due to imaging findings, which were suggestive of pancreatic malignancy. We performed a literature review of this rare condition and present a summary of reported imaging findings. The most distinguishing feature from pancreatic adenocarcinoma is the enhancement pattern, as follicular pancreatitis enhances more than the surrounding pancreatic parenchyma on delayed post-contrast images which is unusual for pancreatic adenocarcinoma. If this benign diagnosis is suggested on imaging, unnecessary surgery and its potential complications may be avoided.

摘要

炎性假瘤在影像学上酷似肿瘤,但实际上代表局灶性炎症。我们报告了一例滤泡性胰腺炎病例,这是一种新近认识的独特的肿块型胰腺慢性胰腺炎,其病理特征为淋巴样浸润伴丰富反应性生发中心。在我们的患者中,滤泡性胰腺炎表现为胰尾肿块,由于影像学表现提示胰腺恶性肿瘤而进行了切除。我们对这种罕见疾病进行了文献复习,并总结了报道的影像学表现。与胰腺腺癌最显著的区别特征是增强模式,滤泡性胰腺炎在延迟期增强扫描上比周围胰腺实质增强更明显,这在胰腺腺癌中是不常见的。如果影像学上提示这种良性诊断,则可能避免不必要的手术及其潜在并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/6938461/90fd1c10e91c/nihms-1542441-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/6938461/20f3d15e179a/nihms-1542441-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/6938461/afd0d6e5daa1/nihms-1542441-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/6938461/342757b2ff4a/nihms-1542441-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/6938461/67f425da66f6/nihms-1542441-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/6938461/90fd1c10e91c/nihms-1542441-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/6938461/20f3d15e179a/nihms-1542441-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/6938461/afd0d6e5daa1/nihms-1542441-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/6938461/342757b2ff4a/nihms-1542441-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/6938461/67f425da66f6/nihms-1542441-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/6938461/90fd1c10e91c/nihms-1542441-f0005.jpg

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本文引用的文献

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Tumefactive Inflammatory Diseases of the Pancreas.胰腺肿块样炎症性疾病。
Am J Pathol. 2019 Jan;189(1):82-93. doi: 10.1016/j.ajpath.2018.05.022.
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Clinicopathological and immunological features of follicular pancreatitis - a distinct disease entity characterised by Th17 activation.滤泡性胰腺炎的临床病理和免疫学特征——一种以 Th17 激活为特征的独特疾病实体。
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Imaging and clinical features of xanthogranulomatous pancreatitis: an analysis of 10 cases at a single institution.
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F- FDG PET/CT helps differentiate autoimmune pancreatitis from pancreatic cancer.F-FDG PET/CT 有助于鉴别自身免疫性胰腺炎与胰腺癌。
BMC Cancer. 2017 Oct 23;17(1):695. doi: 10.1186/s12885-017-3665-y.
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Differentiating Mass-Forming Autoimmune Pancreatitis From Pancreatic Ductal Adenocarcinoma on the Basis of Contrast-Enhanced MRI and DWI Findings.基于增强 MRI 和 DWI 表现鉴别肿块型自身免疫性胰腺炎与胰腺导管腺癌。
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Role of magnetic resonance imaging in the detection and characterization of solid pancreatic nodules: An update.磁共振成像在实性胰腺结节检测与特征描述中的作用:最新进展
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Follicular pancreatitis: a distinct form of chronic pancreatitis-an additional mimic of pancreatic neoplasms.滤泡性胰腺炎:一种独特的慢性胰腺炎形式——胰腺肿瘤的又一模仿者。
Hum Pathol. 2016 Feb;48:154-62. doi: 10.1016/j.humpath.2015.09.017. Epub 2015 Oct 3.
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Diffusion-weighted MR imaging of the pancreas: current status and recommendations.胰腺磁共振弥散加权成像:现状与建议。
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