Mercer University School of Medicine, Savannah, GA, USA.
Department of Pediatrics, Duke University, Durham, NC, USA.
J Perinatol. 2020 Feb;40(2):288-293. doi: 10.1038/s41372-019-0561-0. Epub 2019 Nov 22.
To assess site variability and concomitant respiratory support related to the timing of caffeine discontinuation, and compare clinical characteristics of infants who discontinued caffeine before vs. within the last week of hospitalization.
Cohort study of 81,110 infants <35 weeks gestational age and <1500 g birth weight discharged from 304 neonatal intensive care units from 2001-2016.
The mean postmenstrual age at caffeine discontinuation ranged from 32 to 37 weeks among sites. Respiratory support at the time of discontinuation was common, but variable, with 0-57% of infants receiving positive airway pressure at caffeine discontinuation by site. Infants who discontinued caffeine within the last week of hospitalization had longer total duration of caffeine, but were discharged from the hospital at an earlier postmenstrual age.
There was substantial variability among sites in the timing of caffeine discontinuation before discharge and respiratory support at the time of caffeine discontinuation.
评估与咖啡因停药时间相关的部位变异性和伴随的呼吸支持，并比较在住院最后一周之前和之内停止使用咖啡因的婴儿的临床特征。
对 2001 年至 2016 年间从 304 个新生儿重症监护病房出院的 81110 名胎龄<35 周和出生体重<1500g 的婴儿进行队列研究。
各研究点咖啡因停药时的平均校正后孕周为 32-37 周。停药时的呼吸支持很常见，但存在差异，各研究点有 0-57%的婴儿在停止使用咖啡因时接受气道正压通气。在住院最后一周内停止使用咖啡因的婴儿接受咖啡因治疗的总时间更长，但出院时的校正后孕周更早。
在出院前停止使用咖啡因的时间和停止使用咖啡因时的呼吸支持方面，各研究点之间存在很大的差异。
