[碳酸氢盐血液透析在慢性肾衰竭治疗中的应用]
[Bicarbonate hemodialysis in the therapy of chronic kidney failure].
作者信息
Riabov S I, Shostka G D, Spiridonov V N, Vasil'ev A N, Kozlov V V
出版信息
Ter Arkh. 1988;60(5):76-80.
A method of random sampling was applied to 10 CRI patients to analyze the results of 24 hemodialyses with acetate solution for dialysis (35 mmol/l) and 34 hemodialyses with bicarbonate solution for dialysis (35 mmol/l). Significant reduction of complications like headache, nausea, vomiting, tachycardia, dyspnea, extrasystole was observed in bicarbonate dialysis. The concentration of mean molecular uremic toxins was decreased from 5.75 +/- 0.84 mmol/l in acetate dialysis up to 2.63 +/- 0.21 mmol/l in bicarbonate dialysis. The content of intracellular potassium returned to normal. The concentration of serum cholesterol was decreased from 5.6 +/- 0.4 up to 4.8 +/- 0.2 mmol/l. These data indicated a favorable effect of bicarbonate dialysis on intracellular metabolism. Preliminary data did not confirm the normalizing effect of bicarbonate dialysis on the development of uremic osteopathy.
采用随机抽样方法对10例慢性肾功能不全（CRI）患者进行分析，观察其24次使用醋酸盐透析液（35 mmol/L）透析和34次使用碳酸氢盐透析液（35 mmol/L）透析的结果。在碳酸氢盐透析中，观察到头痛、恶心、呕吐、心动过速、呼吸困难、早搏等并发症显著减少。平均分子尿毒症毒素浓度从醋酸盐透析时的5.75±0.84 mmol/L降至碳酸氢盐透析时的2.63±0.21 mmol/L。细胞内钾含量恢复正常。血清胆固醇浓度从5.6±0.4 mmol/L降至4.8±0.2 mmol/L。这些数据表明碳酸氢盐透析对细胞内代谢有良好作用。初步数据未证实碳酸氢盐透析对尿毒症骨病发展有正常化作用。
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