Department of Pediatrics, Division of Nephrology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Kidney Int. 2019 Dec;96(6):1277-1279. doi: 10.1016/j.kint.2019.09.004.
Ferric citrate is a phosphate binder that may also be used to treat iron-deficiency anemia. In human studies, ferric citrate treatment in the setting of chronic kidney disease has been associated with effective phosphate control, improved iron and hematologic parameters, and decreased fibroblast growth factor 23 levels. In the present study, mice with chronic kidney disease treated with ferric citrate have similarly improved biochemical profiles, but also have improved cardiac and renal function and prolonged survival.
柠檬酸铁是一种磷酸盐结合剂，也可用于治疗缺铁性贫血。在人体研究中，柠檬酸铁治疗慢性肾脏病与有效控制磷酸盐、改善铁和血液参数以及降低成纤维细胞生长因子 23 水平有关。在本研究中，用柠檬酸铁治疗的慢性肾脏病小鼠同样改善了生化指标，但也改善了心肾功能并延长了生存时间。
