Children's Nutrition Research Center; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, 400014, China.
Children's Nutrition Research Center; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, 400014, China.
Reprod Toxicol. 2020 Jan;91:109-115. doi: 10.1016/j.reprotox.2019.11.009. Epub 2019 Nov 21.
To explore possible associations between maternal use of micronutrient supplements and the subsequent vitamin levels and symptoms in offspring with autism spectrum disorder (ASD), a total of 416 children with ASD and 201 typically developing (TD) children were enrolled. The children born to mothers without folic acid (FA) and micronutrient supplementation during pregnancy had more severe social cognition impairments, social communication impairments, autism behaviour mannerisms, developmental delays in adaptive and gross motor behaviour and gastrointestinal problems than children born to mothers who used FA and micronutrient supplements (P＜0.05). Interestingly, there was an association between maternal micronutrient supplementation and vitamin A (VA), vitamin D (VD) and folate levels in the ASD children (P<0.05), and levels of these vitamins also were associated with symptoms of ASD. Maternal FA and/or micronutrient supplementation may potentially moderate the symptoms of ASD. Interrupting the chain of micronutrient deficiencies between pregnant mothers and children may be beneficial in improving symptoms of ASD.
为了探索母亲使用微量营养素补充剂与自闭症谱系障碍（ASD）后代随后的维生素水平和症状之间可能存在的关联，共纳入了 416 名 ASD 儿童和 201 名典型发育（TD）儿童。与怀孕期间未服用叶酸（FA）和多种微量营养素补充剂的母亲所生的儿童相比，有 FA 和多种微量营养素补充剂的母亲所生的儿童在社会认知障碍、社会沟通障碍、自闭症行为习惯、适应和粗大运动行为发育迟缓以及胃肠道问题方面更为严重（P＜0.05）。有趣的是，母亲微量营养素补充与 ASD 儿童的维生素 A（VA）、维生素 D（VD）和叶酸水平之间存在关联（P＜0.05），并且这些维生素水平也与 ASD 的症状相关。母亲的 FA 和/或多种微量营养素补充可能潜在地调节 ASD 的症状。在孕妇和儿童之间阻断微量营养素缺乏的链条可能有助于改善 ASD 的症状。
