Böttger H C, Oellerich M, Sybrecht G W
Zentren für Laboratoriumsmedizin und Innere Medizin, Medizinische Hochschule Hannover, F.R.G.
Ther Drug Monit. 1988;10(3):280-6. doi: 10.1097/00007691-198803000-00007.
Dosage prediction methods for optimization of aminoglycoside therapy were evaluated in 19 critically ill patients. Two different three-point methods and a novel Bayesian method were used. The predictive accuracy and precision of all tested methods were clinically satisfactory. The time needed for the necessary calculations was 10-15 min. After administration of predicted dosages, approximately 90% of the observed peak and trough aminoglycoside serum concentrations fell within the therapeutic range. Without systematic use of these prediction methods, only approximately 40% of tobramycin peak serum concentrations and 80% of trough serum concentrations were within the therapeutic range. Daily dosage adjustments particularly in patients with rapid changes of aminoglycoside clearance are greatly facilitated by use of these prediction methods. These findings suggest that all of the dosage prediction methods tested are well suited for optimization of aminoglycoside dosage regimens.
在19例重症患者中评估了用于优化氨基糖苷类药物治疗的剂量预测方法。使用了两种不同的三点法和一种新的贝叶斯方法。所有测试方法的预测准确性和精密度在临床上都令人满意。必要计算所需的时间为10 - 15分钟。给予预测剂量后，观察到的氨基糖苷类药物血清峰浓度和谷浓度约90%落在治疗范围内。若不系统使用这些预测方法，只有约40%的妥布霉素血清峰浓度和80%的谷浓度在治疗范围内。使用这些预测方法极大地促进了每日剂量调整，尤其是在氨基糖苷类药物清除率快速变化的患者中。这些发现表明，所有测试的剂量预测方法都非常适合优化氨基糖苷类药物的给药方案。
