长链非编码 RNA LINC-PINT 和 LINC00599 多态性与中国人的高原性肺水肿有关。
Long Non-coding RNA LINC-PINT and LINC00599 Polymorphisms are Associated With High-altitude Pulmonary Edema in Chinese.
机构信息
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xianyang, Shaanxi, China; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xianyang, Shaanxi, China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Department of Internal Medicine, Affiliated Hospital of Xizang Minzu University, Xianyang, Shaanxi, China.
出版信息
Arch Bronconeumol (Engl Ed). 2020 Jun;56(6):360-364. doi: 10.1016/j.arbres.2019.09.021. Epub 2019 Nov 21.
BACKGROUND
High-altitude pulmonary edema (HAPE) is a kind of non-cardiogenic edema with high incidence and life-threatening. This study was designed to explore the association of LINC-PINT and LINC00599 polymorphisms with HAPE susceptibility.
METHODS
This study included 244 HAPE patients and 243 age-, sex-matched healthy controls from the Chinese population. The genotypes of polymorphisms were detected using the Agena MassARRAY. The relationship between polymorphisms and HAPE risk was evaluated using a χ test with an odds ratio (OR) and 95% confidence intervals (CIs) in multiple genetic models.
RESULTS
We observe a significant association between the rs157928 and decreased HAPE risk in genotype model (OR=0.65, 95% CI=0.43-0.98, p=0.038). The subgroup analysis results indicated that rs2272026 was associated with a decreased risk of HAPE in younger patients with age ≤32 (codominant model: p=0.006; recessive model: p=0.005 additive model: p=0.018; and allele model: p=0.012; rs72625676, codominant model: p=0.038; recessive model: p=0.037). Among patients older than 32 years, there was a significantly increased risk of HAPE associated with the rs2272026 and rs1962430 (rs2272026: genotype model: p=0.049; recessive model: p=0.029; rs1962430: genotype model: p=0.024; recessive model: p=0.020). Nevertheless, rs157928 had relationship with significantly reducing the risk of HAPE in the genotype model (p=0.018).
CONCLUSION
Our study suggests that LINC-PINT and LINC00599 polymorphisms are associated with HAPE susceptibility in Chinese population.
背景
高原肺水肿（HAPE）是一种高发病率和危及生命的非心源性水肿。本研究旨在探讨 LINC-PINT 和 LINC00599 多态性与 HAPE 易感性的关系。
方法
本研究纳入了来自中国人群的 244 例 HAPE 患者和 243 名年龄、性别匹配的健康对照者。采用 Agena MassARRAY 检测多态性的基因型。采用 χ2 检验和比值比（OR）及其 95%置信区间（CI）在多种遗传模型中评估多态性与 HAPE 风险的关系。
结果
我们观察到 rs157928 与基因型模型中 HAPE 风险降低显著相关（OR=0.65，95%CI=0.43-0.98，p=0.038）。亚组分析结果表明，rs2272026 与年龄≤32 岁的年轻患者 HAPE 风险降低相关（共显性模型：p=0.006；隐性模型：p=0.005；加性模型：p=0.018；等位基因模型：p=0.012；rs72625676，共显性模型：p=0.038；隐性模型：p=0.037）。在年龄大于 32 岁的患者中，rs2272026 和 rs1962430 与 HAPE 风险显著增加相关（rs2272026：基因型模型：p=0.049；隐性模型：p=0.029；rs1962430：基因型模型：p=0.024；隐性模型：p=0.020）。然而，rs157928 与 HAPE 风险显著降低相关，在基因型模型中（p=0.018）。
结论
本研究表明，LINC-PINT 和 LINC00599 多态性与中国人群的 HAPE 易感性相关。
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