Department of Gastrointestinal Surgery, Hainan Cancer Hospital, Haikou, Hainan, China.
Department of Gastroenterology, Hainan Cancer Hospital, Haikou, Hainan, China.
Ann Med. 2024 Dec;56(1):2397569. doi: 10.1080/07853890.2024.2397569. Epub 2024 Sep 2.
Esophageal squamous cell carcinoma (ESCC) is a malignant tumor with high incidence and mortality rates worldwide. This study aimed to investigate the correlation between polymorphisms and ESCC risk in the Hainan Han population.
A total of 391 patients with ESCC and 452 healthy controls were enrolled to evaluate the effect of SNPs (single nucleotide polymorphisms) on ESCC susceptibility. Associations were evaluated by calculating odds ratios (OR) and 95% confidence intervals (CIs). Multifactor dimensionality reduction analysis was performed to explore the association between SNP-SNP interactions and ESCC susceptibility. We further determined the correlation between clinical indicators and SNP in patients with ESCC.
Our study showed that rs157916 (OR 0.63, = 0.011) and rs157928 (OR 0.80, = 0.021) were associated with a decreased risk of ESCC. Stratified analysis indicated that rs157916 could decrease the risk of ESCC in people aged >64 years, in males, and non-drinkers (OR 0.58, = 0.042; OR 0.58, = 0.010; OR 0.62, = 0.025, respectively). Rs16873842 was related to a decreased risk of ESCC in males (OR 0.70, = 0.015). Rs7801029 was associated with ESCC risk in females (OR 0.39, = 0.033) and non-drinkers (OR 0.68, = 0.040). Rs7781295 decreased the ESCC risk in smokers (OR 0.58, = 0.046) and drinkers (OR 0.58, = 0.046). In addition, rs157928 played a protective role in ESCC risk in females (OR 0.39, = 0.033) and non-smokers (OR 0.32, = 0.006). Additionally, the best predictive model for ESCC was a combination of rs157916, rs16873842, rs7801029, rs7781295, rs28662387, and rs157928.
Our study revealed that polymorphisms were associated with ESCC risk.
食管鳞状细胞癌（ESCC）是一种在全球范围内发病率和死亡率都很高的恶性肿瘤。本研究旨在探讨海南汉族人群中 SNP 与 ESCC 风险的相关性。
共纳入 391 例 ESCC 患者和 452 例健康对照者，评估 SNP 对 ESCC 易感性的影响。通过计算比值比（OR）和 95%置信区间（CI）来评估关联。多因素维度缩减分析用于探讨 SNP-SNP 相互作用与 ESCC 易感性的关联。我们进一步确定了 ESCC 患者的临床指标与 SNP 之间的相关性。
本研究表明，rs157916（OR 0.63，=0.011）和 rs157928（OR 0.80，=0.021）与 ESCC 风险降低相关。分层分析表明，rs157916 可降低 >64 岁、男性和非饮酒者患 ESCC 的风险（OR 0.58，=0.042；OR 0.58，=0.010；OR 0.62，=0.025）。rs16873842 与男性 ESCC 风险降低相关（OR 0.70，=0.015）。rs7801029 与女性（OR 0.39，=0.033）和非饮酒者（OR 0.68，=0.040）的 ESCC 风险相关。rs7781295 降低了吸烟者（OR 0.58，=0.046）和饮酒者（OR 0.58，=0.046）患 ESCC 的风险。此外，rs157928 对女性（OR 0.39，=0.033）和非吸烟者（OR 0.32，=0.006）的 ESCC 风险具有保护作用。此外，ESCC 的最佳预测模型是 rs157916、rs16873842、rs7801029、rs7781295、rs28662387 和 rs157928 的组合。
本研究表明，SNP 与 ESCC 风险相关。
