Le Thai B, Dumont M, Michel A, Erlinger S, Houssin D
Laboratoire de Recherche Chirurgicale, Hôpital Cochin, Paris, France.
Transplantation. 1988 Oct;46(4):510-2. doi: 10.1097/00007890-198810000-00008.
Cyclosporine administration in patients with organ transplants may cause cholestasis. In the rat, intraperitoneal administration of cyclosporine, 10 mg/kg, for three weeks did not cause liver function test abnormalities or hepatic histological lesions. However a significant reduction of bile flow and bile acid secretion rates was observed. The fact that reduction of bile flow was related to a decrease of the bile acid-independent flow suggests that cyclosporine-induced cholestasis results from an inhibition of bile acid secretion. Whether this inhibition is caused by the parental molecule or by cyclosporine metabolites needs to be clarified.
器官移植患者使用环孢素可能会导致胆汁淤积。在大鼠中，腹腔注射10mg/kg环孢素，持续三周，未引起肝功能测试异常或肝脏组织学损伤。然而，观察到胆汁流量和胆汁酸分泌率显著降低。胆汁流量减少与非胆汁酸依赖性胆汁流量减少有关，这一事实表明，环孢素诱导的胆汁淤积是由胆汁酸分泌受抑制所致。这种抑制是由母体分子还是环孢素代谢产物引起的，尚待阐明。
