Zhang Fusong, Lai Qi, Shi Xiaodong, Song Zhiguang
Department of Chemistry, Jilin University, Changchun, Jilin 130021, China.
Department of Chemistry, University of South Florida, Tampa FL33620, United States.
Chin Chem Lett. 2019 Feb;30(2):392-394. doi: 10.1016/j.cclet.2018.05.036. Epub 2018 May 24.
A gold-catalyzed three-component coupling reaction (A3 reaction) was developed as an efficient approach for the synthesis of challenging 2, 4-disubstituted quinoline derivatives. Compared to previously reported Cu/Au bi-catalyst system, this protocol enables achieving A3 reaction only in the presence of triazole-gold catalyst. Notably, 4-alkyl substituted or 2-alkyl substituted quinoline derivatives were obtained with good yields, which highlighted the unique advantage of this new strategy.
一种金催化的三组分偶联反应（A3反应）被开发为一种合成具有挑战性的2,4-二取代喹啉衍生物的有效方法。与先前报道的铜/金双催化剂体系相比，该方法仅在三唑-金催化剂存在下就能实现A3反应。值得注意的是，4-烷基取代或2-烷基取代的喹啉衍生物能以良好的产率得到，这突出了这种新策略的独特优势。
