Bremner I, Humphries W R, Morrice P C, Carlyle W W
Biochemistry Division, Rowett Research Institute, Bucksburn, Aberdeen.
Vet Rec. 1988 Aug 27;123(9):217-8. doi: 10.1136/vr.123.9.217.
The benefits of the inclusion of cobalt and selenium supplements in anthelmintic preparations were demonstrated in a 10 week trial with cobalt- and selenium-deficient blackface wethers. The anthelmintics were based on oxfendazole and on levamisole plus oxyclozanide; three doses provided, in total, 38 mg cobalt and 7.2 or 11.3 mg selenium. Administration of the supplements prevented the weight loss and reduction in food intake observed in unsupplemented animals. Blood glutathione peroxidase activities were restored to normal and increases in serum vitamin B12 levels were observed which were consistent with the prevention of both cobalt and selenium deficiencies.
在一项针对钴和硒缺乏的黑脸阉羊进行的为期10周的试验中，证明了在驱虫制剂中添加钴和硒补充剂的益处。驱虫药以奥芬达唑以及左旋咪唑加羟氯扎胺为基础；三种剂量总共提供了38毫克钴和7.2或11.3毫克硒。补充剂的施用防止了未补充动物出现的体重减轻和食物摄入量减少的情况。血液谷胱甘肽过氧化物酶活性恢复正常，并且观察到血清维生素B12水平升高，这与预防钴和硒缺乏均相符。
