影响端粒长度的基因变异与前列腺癌风险相关。
Genetic variants in influencing telomere length are associated with prostate cancer risk.
作者信息
Gu Cheng-Yuan, Jin Sheng-Ming, Qin Xiao-Jian, Zhu Yao, Bo Dai, Lin Guo-Wen, Shi Guo-Hai, Ye Ding-Wei
机构信息
Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
出版信息
J Cancer. 2019 Oct 15;10(24):6170-6174. doi: 10.7150/jca.35917. eCollection 2019.
Telomere length measured in lymphocytes has been evaluated as a potential biomarker for prostate cancer (PCa) risk. Identifying genetic variants that affect telomere length and testing their association with disease could clarify any causal role. We therefore investigated associations between genetic variants in three telomere length-related genes and PCa risk in a case-control study. The influence of these variants on the leukocyte telomere lengths was then appraised by real-time PCR. rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk. These two risk single nucleotide polymorphisms (SNPs) (OR: 0.59; 95% CI: 0.39-0.89, = 0.012 and OR: 0.58; 95% CI: 0.38-0.87, = 0.009, respectively) and another SNP rs1136410 (OR: 1.53; 95% CI: 1.01-2.31, = 0.043) were also associated with leukocyte telomere length. These findings support that genetic determinants of telomere length may influence PCa risk.
淋巴细胞中测量的端粒长度已被评估为前列腺癌（PCa）风险的潜在生物标志物。识别影响端粒长度的基因变异并测试它们与疾病的关联可以阐明任何因果作用。因此，我们在一项病例对照研究中调查了三个端粒长度相关基因中的基因变异与PCa风险之间的关联。然后通过实时PCR评估这些变异对白细胞端粒长度的影响。rs2297441[比值比（OR）：1.23；95%置信区间（CI）：1.03 - 1.46，P = 0.021]和rs3208008（OR：1.23；95%CI：1.03 - 1.46）与PCa风险相关。这两个风险单核苷酸多态性（SNP）（分别为OR：0.59；95%CI：0.39 - 0.89，P = 0.012和OR：0.58；95%CI：0.38 - 0.87，P = 0.009）以及另一个SNP rs1136410（OR：1.53；95%CI：1.01 - 2.31，P = 0.043）也与白细胞端粒长度相关。这些发现支持端粒长度的遗传决定因素可能影响PCa风险。
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