Andrade Felipe César, Vergetti Vinicius, Cozza Gabriella, Falcao Maria Clara, Azevedo Gustavo
Medicine, Faculdade Pernambucana De Saude, Recife, BRA.
Medicine, Faculdade Pernambuca De Saude, Recife, BRA.
Cureus. 2019 Oct 9;11(10):e5876. doi: 10.7759/cureus.5876.
Amyotrophic lateral sclerosis (ALS)-like syndrome refers to a group of conditions whose outcome is similar to that of amyotrophic lateral sclerosis, but with different characteristics in the initial phase and response to therapy. The involvement of an earlier age group, the subacute course, and the stabilization or improvement of the clinical condition during the treatment are most important. There is still no evidence of an association between amyotrophic lateral sclerosis-like syndrome and chikungunya (CHK) infection in the literature. This report was intended to review this syndrome and present a case that occurred after the epidemic of CHK in Pernambuco in 2016. CHK is a fast-onset febrile illness characterized by intense asthenia, arthralgia, myalgia, headache, and skin rash. Reports range from encephalitis, optic neuritis, myeloradiculitis to Guillain-Barré syndrome, generating drastic sequelae such as mental deficiency, blindness, and persistent paralysis. This is the first case report of a possible association of ALS-like syndrome and chikungunya infection. CHK infection may cause ALS-like syndrome. There is a need for further research in this field to develop therapies for neurological complications such as that of CHK.
肌萎缩侧索硬化症（ALS）样综合征是指一组疾病，其预后与肌萎缩侧索硬化症相似，但在初始阶段和对治疗的反应方面具有不同特征。发病年龄较轻、亚急性病程以及治疗期间临床状况的稳定或改善最为重要。文献中仍无证据表明肌萎缩侧索硬化症样综合征与基孔肯雅热（CHK）感染之间存在关联。本报告旨在对该综合征进行综述，并呈现一例2016年伯南布哥州基孔肯雅热疫情后发生的病例。基孔肯雅热是一种起病迅速的发热性疾病，其特征为严重乏力、关节痛、肌痛、头痛和皮疹。报告范围从脑炎、视神经炎、脊髓神经根炎到格林-巴利综合征，会产生诸如智力缺陷、失明和持续性瘫痪等严重后遗症。这是首例关于肌萎缩侧索硬化症样综合征与基孔肯雅热感染可能存在关联的病例报告。基孔肯雅热感染可能导致肌萎缩侧索硬化症样综合征。该领域需要进一步研究，以开发针对基孔肯雅热等神经并发症的治疗方法。
