Pd-Catalyzed Enantioselective Double Heck Reaction.

An asymmetric Pd-catalyzed intramolecular followed by an intermolecular double Heck reaction of arenediazonium salts with simple alkenes is disclosed. This reaction features mild reaction conditions, simple operation, and excellent functional group tolerance and provides a rapid access to functionalized dihydrobenzofurans bearing all-carbon quaternary centers in good regioselectivity (>95/5) and enantioselectivity (90-99% ee).