David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Pediatr Dermatol. 2020 Jan;37(1):192-195. doi: 10.1111/pde.14066. Epub 2019 Nov 25.
An increased number of melanocytic nevi and lentigines have been reported in patients with two types of autosomal recessive congenital ichthyosis (ARCI): lamellar ichthyosis and nonbullous congenital ichthyosiform erythroderma. These melanocytic lesions may have clinical and dermoscopic features of atypia, necessitating close surveillance. Here, we report two interesting cases of pediatric patients with harlequin ichthyosis (HI) who developed increased melanocytic nevi and lentigines. These cases are unique in that the patients presented at a younger age and one patient had a darker skin phototype than previously described in the literature.
已报道两种常染色体隐性先天性鱼鳞病（ARCI）：板层状鱼鳞病和非大疱性先天性鱼鳞样红皮病患者的黑素细胞痣和色素沉着增多。这些黑素细胞病变可能具有异型性的临床和皮肤镜特征，需要密切监测。在此，我们报告了两例有趣的儿童哈林顿鱼鳞病（HI）患者，他们出现了黑素细胞痣和色素沉着增多。这些病例的独特之处在于患者的发病年龄更小，且一名患者的皮肤光型比文献中先前描述的更黑。
