Departamento de Bioquímica y Biología Molecular, Campus de Excelencia Internacional Agroalimentario CeiA3, Universidad de Córdoba, Campus de Rabanales, Edificio Severo Ochoa, 14071, Córdoba, Spain.
Departamento de Química Agrícola, Universidad de Córdoba, Campus de Rabanales, Edificio Marie Curie, 14071, Córdoba, Spain.
Food Chem Toxicol. 2020 Feb;136:110984. doi: 10.1016/j.fct.2019.110984. Epub 2019 Nov 23.
Aging is characterized by deterioration of biomolecules and impaired stress responses that make the elderly especially vulnerable to environmental pollutants. The pesticide p,p'-DDE is a DDT derivative that generates great concern because of its wide distribution and its harmful effects on both human health and the environment. We analyzed here the biological responses elicited by p,p'-DDE exposure in the liver of aged Mus spretus mice. Data demonstrate that the elderly constitute a population especially sensitive to this noxious environmental pollutant. We also demonstrated here that the daily consumption of sun-dried Pedro Ximénez (PX) white-grape must (PXM) protects the liver of aged mice from both the age and the damages caused by p,p'-DDE exposure. The PXM activity was exerted through the restoration of the hepatic metabolisms of lipids and carbohydrates and, probably, is a consequence of the ability of this polyphenol-rich mixture to avoid oxidative stress. Nutritional interventions including PXM, which ameliorates the effects of unavoidable exposure to pesticides in our food, are helpful tools that can help elderly populations to enjoy a healthy and expanded lifetime.
衰老是生物分子恶化和应激反应受损的特征，这使得老年人特别容易受到环境污染物的影响。农药 p,p'-DDE 是滴滴涕的衍生物，由于其广泛分布及其对人类健康和环境的有害影响而引起了极大的关注。我们在这里分析了 p,p'-DDE 暴露在衰老的 Mus spretus 小鼠肝脏中引起的生物学反应。数据表明，老年人是对这种有害环境污染物特别敏感的人群。我们还在这里证明，每天食用晒干的 Pedro Ximénez（PX）白葡萄汁（PXM）可以保护老年小鼠的肝脏免受年龄和 p,p'-DDE 暴露造成的损害。PXM 的作用是通过恢复肝脏的脂质和碳水化合物代谢来实现的，可能是由于这种富含多酚的混合物能够避免氧化应激。包括 PXM 在内的营养干预措施可以帮助改善我们食物中不可避免的农药暴露的影响，是有助于老年人享受健康和延长寿命的有用工具。
