利伐沙班致急性颈椎硬膜外血肿：一例报告及文献复习
Rivaroxaban-induced acute cervical spine epidural hematoma: Report of a case and review.
作者信息
Rahimizadeh Abolfazl, Malekmohammadi Zahed, Williamson Walter L, Rahimizadeh Shaghayegh, Amirzadeh Mahan, Asgari Naser
机构信息
Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Surg Neurol Int. 2019 Oct 25;10:210. doi: 10.25259/SNI_390_2019. eCollection 2019.
BACKGROUND
Spontaneous spinal epidural hematomas (SEHs) due to the utilization of factor Xa inhibitors are rare.
CASE DESCRIPTION
A 66-year-old female presented with a Brown-Sequard syndrome attributed to a cervical epidural hematoma secondary to the utilization of rivaroxaban, one of the factor Xa inhibitors. Following a cervical laminectomy for the evacuation of the hematoma, the patient completely recovered.
CONCLUSION
A spinal hemorrhagic event should be suspected in patients receiving factor Xa inhibitor drugs. Here, we had an elderly female on rivaroxaban experienced the acute onset of neck/back pain associated with a Brown-Sequard syndrome. A literature review showed that this is the seventh example of SEH occurring as a result of the use of anticoagulation drugs (OACDs; e.g., including Xa inhibitors).
背景
因使用Xa因子抑制剂导致的自发性脊髓硬膜外血肿（SEH）较为罕见。
病例描述
一名66岁女性因使用Xa因子抑制剂之一的利伐沙班继发颈椎硬膜外血肿，出现布朗 - 色夸综合征。在进行颈椎椎板切除术以清除血肿后，患者完全康复。
结论
接受Xa因子抑制剂药物治疗的患者应怀疑发生脊髓出血事件。在此，我们有一名服用利伐沙班的老年女性经历了与布朗 - 色夸综合征相关的颈部/背部疼痛急性发作。文献综述表明，这是因使用抗凝血药物（口服抗凝药；例如，包括Xa抑制剂）导致SEH的第七个病例。
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