Minderhoud J M, van der Hoeven J H, Prange A J
Department of Neurology, University Hospital, Groningen, The Netherlands.
Acta Neurol Scand. 1988 Jul;78(1):10-5. doi: 10.1111/j.1600-0404.1988.tb03611.x.
In studies on the natural course of multiple sclerosis (MS), several forms of the disease are distinguished. The most important are the relapsing remitting and the chronic progressive forms. The relationship between these remains unclear. In a prospective epidemiological survey we studied the course of MS using the year in which the chronic-progressive phase started as a landmark. The reliability of this "year of progression" was examined in an observer agreement study. Data were acquired from 342 patients. Progression of the handicap was most rapid in case of a secondary progressive course, female sex, high relapse rate in the preceding remitting phase and "year of progression" at a higher age. Survival after the "year of progression" was lowest in the secondary progressive group. Determining the "year of progression" seems to be significant for the prognosis.
在对多发性硬化症（MS）自然病程的研究中，区分出了该疾病的几种形式。其中最重要的是复发缓解型和慢性进展型。二者之间的关系仍不明确。在一项前瞻性流行病学调查中，我们以慢性进展期开始的年份为标志研究了MS的病程。在一项观察者一致性研究中检验了这个“进展年份”的可靠性。数据来自342例患者。在继发进展型病程、女性、既往缓解期高复发率以及较高年龄出现“进展年份”的情况下，残疾进展最为迅速。继发进展组在“进展年份”后的生存率最低。确定“进展年份”似乎对预后具有重要意义。
