肝细胞癌中HINT2表达下调的临床意义

Clinical significance of down-regulated HINT2 in hepatocellular carcinoma.

作者信息

Zhou Dong-Kai, Qian Xiao-Hui, Cheng Jun, Chen Ling-Hui, Wang Wei-Lin

机构信息

Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital.

Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province.

出版信息

Medicine (Baltimore). 2019 Nov;98(48):e17815. doi: 10.1097/MD.0000000000017815.

DOI:10.1097/MD.0000000000017815

PMID:31770197

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6890357/

Abstract

To study the clinical significance of HINT2 expression in patients with HCC.We investigated HINT2 mRNA expression in tumors and adjacent non-tumor hepatic tissues from 106 HCC patients using quantitative real-time PCR. Appropriate statistical methods were then applied to assess the relationships between the HINT2 mRNA level and clinical parameters.HINT2 was significantly down-regulated in HCC (P < .0001). No significant correlation was found between HINT2 expression and clinicopathological factors in HCC patients. A Kaplan-Meier survival curve showed that HINT2 expression is related to recurrence-free survival (P < .05). Multivariate analyses revealed that tumor size and HINT2 expression are risk factors for HCC recurrence.HINT2 is down-regulated in HCC, and low HINT2 expression predicts earlier tumor recurrence. HINT2 expression may serve as a prognostic indicator of recurrence in HCC.

摘要

为研究HINT2表达在肝癌患者中的临床意义。我们采用定量实时PCR检测了106例肝癌患者肿瘤组织及癌旁非肿瘤肝组织中HINT2 mRNA的表达。随后应用适当的统计方法评估HINT2 mRNA水平与临床参数之间的关系。HINT2在肝癌中显著下调（P<0.0001）。在肝癌患者中，未发现HINT2表达与临床病理因素之间存在显著相关性。Kaplan-Meier生存曲线显示，HINT2表达与无复发生存相关（P<0.05）。多因素分析显示，肿瘤大小和HINT2表达是肝癌复发的危险因素。HINT2在肝癌中下调，低HINT2表达预示肿瘤复发较早。HINT2表达可能作为肝癌复发的预后指标。