一项病例对照研究中结直肠癌与唑吡坦使用之间的关联。
Association between colorectal cancer and zolpidem use in a case-control study.
作者信息
Lai Shih-Wei, Lin Cheng-Li, Liao Kuan-Fu
机构信息
College of Medicine, China Medical University.
Department of Family Medicine.
出版信息
Medicine (Baltimore). 2019 Nov;98(48):e18127. doi: 10.1097/MD.0000000000018127.
This study aimed to examine the association between colorectal cancer and zolpidem use in Taiwan.A case-control study was conducted using the database of Taiwan National Health Insurance Program from 2000 to 2013. Participants aged 20 to 84 years with newly diagnosed colorectal cancer were selected as the cases. Sex-matched and age-matched participants without colorectal cancer were randomly selected as the matched controls. The odds ratio and 95% confidence interval for colorectal cancer associated with zolpidem use were calculated by the multivariable logistic regression model.There were 4912 cases with colorectal cancer and 4912 matched controls without colorectal cancer. The mean age was 63 years and 58% were male participants. After adjustment for co-variables, the multivariable logistic regression model disclosed that there was no statistical association between colorectal cancer and zolpidem use (adjusted OR 1.05, 95% CI 0.95-1.15).No statistical association can be detected between colorectal cancer and zolpidem use in Taiwan.
本研究旨在探讨台湾地区结直肠癌与唑吡坦使用之间的关联。利用2000年至2013年台湾全民健康保险计划数据库进行了一项病例对照研究。将年龄在20至84岁之间新诊断为结直肠癌的参与者选为病例。随机选择年龄和性别匹配且无结直肠癌的参与者作为匹配对照。采用多变量逻辑回归模型计算与唑吡坦使用相关的结直肠癌的比值比和95%置信区间。共有4912例结直肠癌病例和4912例无结直肠癌的匹配对照。平均年龄为63岁，男性参与者占58%。在对协变量进行调整后，多变量逻辑回归模型显示结直肠癌与唑吡坦使用之间无统计学关联（调整后比值比为1.05，95%置信区间为0.95 - 1.15）。在台湾地区，未检测到结直肠癌与唑吡坦使用之间存在统计学关联。
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