肿瘤相关中性粒细胞与肺癌的研究进展
[Research Progress of Tumor-Associated Neutrophils and Lung Cancer].
作者信息
Zhou Jinhua, Jiang Shulong, Wang Wei, Liu Ruijuan
机构信息
Jining No.1 People's Hospital, Jining 272000, China.
The Second Hospital of Shandong University, Jinan 250033, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2019 Nov 20;22(11):727-731. doi: 10.3779/j.issn.1009-3419.2019.11.07.
Abstract
Lung cancer is a global disease with high morbidity and mortality, which seriously affects human health. The long-term existence of chronic pulmonary inflammation is closely related to the occurrence and development of lung cancer, neutrophils are not only involved in acute and chronic inflammation, but also in the composition of tumor microenvironment (TME), which is closely related to the occurrence and development of tumors. Recent studies have found that tumor-associated neutrophils (TANs) play an important role in the occurrence and development of lung cancer. This article reviews the role, mechanism and clinical significance of tumor-related neutrophils in lung cancer.
摘要
肺癌是一种全球发病率和死亡率都很高的疾病，严重影响人类健康。慢性肺部炎症的长期存在与肺癌的发生发展密切相关，中性粒细胞不仅参与急性和慢性炎症，还参与肿瘤微环境（TME）的构成，而肿瘤微环境与肿瘤的发生发展密切相关。最近的研究发现，肿瘤相关中性粒细胞（TANs）在肺癌的发生发展中起重要作用。本文综述了肿瘤相关中性粒细胞在肺癌中的作用、机制及临床意义。
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