Department of Biotechnology and Bioinformatics, Yogi Vemana University, Kadapa, Andhra Pradesh 516 005, India.
Department of Genetics and Genomics, Yogi Vemana University, Kadapa, Andhra Pradesh 516 005, India.
Curr Drug Metab. 2019;20(12):967-976. doi: 10.2174/1389200220666191127110857.
Cancer and other disorders such as inflammation, autoimmune diseases and diabetes are the major health problems observed all over the world. Therefore, identifying a therapeutic target molecule for the treatment of these diseases is urgently needed to benefit public health. C-Phycocyanin (C-PC) is an important light yielding pigment intermittently systematized in the cyanobacterial species along with other algal species. It has numerous applications in the field of biotechnology and drug industry and also possesses antioxidant, anticancer, antiinflammatory, enhanced immune function, including liver and kidney protection properties. The molecular mechanism of action of C-PC for its anticancer activity could be the blockage of cell cycle progression, inducing apoptosis and autophagy in cancer cells.
The current review summarizes an update on therapeutic applications of C-PC, its mechanism of action and mainly focuses on the recent development in the field of C-PC as a drug that exhibits beneficial effects against various human diseases including cancer and inflammation.
The data from various studies suggest the therapeutic applications of C-PC such as anti-cancer activity, anti-inflammation, anti-angiogenic activity and healing capacity of certain autoimmune disorders. Mechanism of action of C-PC for its anticancer activity is the blockage of cell cycle progression, inducing apoptosis and autophagy in cancer cells. The future perspective of C-PC is to identify and define the molecular mechanism of its anti-cancer, anti-inflammatory and antioxidant activities, which would shed light on our knowledge on therapeutic applications of C-PC and may contribute significant benefits to global public health.
癌症和其他疾病（如炎症、自身免疫性疾病和糖尿病）是全球面临的主要健康问题。因此，迫切需要确定一种治疗这些疾病的治疗靶点分子，以造福公众健康。藻蓝蛋白（C-PC）是一种重要的发光色素，在蓝藻和其他藻类物种中间歇性地系统化存在。它在生物技术和制药工业领域有许多应用，并且具有抗氧化、抗癌、抗炎、增强免疫功能的特性，包括对肝脏和肾脏的保护作用。C-PC 发挥抗癌作用的分子机制可能是阻止细胞周期进程，诱导癌细胞凋亡和自噬。
本综述总结了 C-PC 的治疗应用、作用机制的最新进展，主要关注 C-PC 在作为一种药物方面的最新发展，该药物对包括癌症和炎症在内的各种人类疾病具有有益的作用。
来自各种研究的数据表明，C-PC 具有治疗应用，如抗癌活性、抗炎、抗血管生成活性和某些自身免疫性疾病的愈合能力。C-PC 发挥抗癌活性的作用机制是阻止细胞周期进程，诱导癌细胞凋亡和自噬。C-PC 的未来前景是确定和定义其抗癌、抗炎和抗氧化活性的分子机制，这将有助于我们了解 C-PC 的治疗应用，并可能为全球公众健康带来重大益处。
