Mendelow B, Grobicki D, de la Hunt M, Derman D, Macdougall L, Katz J
S Afr Med J. 1979 Sep 1;56(10):385-8.
Haemopoietic cells from patients with leukaemia and aplastic anaemia were studied in vitro with a standard soft agar tissue culture method. In the leukaemic patients a range of growth patterns was observed, but in most cases the results indicated that leukaemic cells retain the capacity to proliferate in response to the normal physiological neutropoieic regulator, colony-stimulating factor. In some patients, cells were apparently also capable of normal morphological maturation. These findings support the work of others in suggesting that leukaemic cells may be induced to behave normally in vitro, at least in some cases, raising possibilities of radically altered approaches to further therapy. In aplastic anaemia granulocyte-macrophage progenitor cells are greatly diminished.
采用标准软琼脂组织培养方法对白血病和再生障碍性贫血患者的造血细胞进行了体外研究。在白血病患者中观察到一系列生长模式，但在大多数情况下，结果表明白血病细胞保留了对正常生理性中性粒细胞生成调节因子——集落刺激因子作出增殖反应的能力。在一些患者中，细胞显然也能够进行正常的形态成熟。这些发现支持了其他人的研究工作，表明白血病细胞至少在某些情况下可能在体外被诱导表现正常，这为进一步治疗方法的彻底改变带来了可能性。在再生障碍性贫血中，粒细胞 - 巨噬细胞祖细胞大大减少。
