Park Deborah Yae-Jung, Krishnamurthi Smitha, Chahal Prabhleen, Downs-Kelly Erinn, Morris-Stiff Gareth
Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Hematology and Medical Oncology, Cleveland Clinic, Cleveland, Ohio, USA.
BMJ Case Rep. 2019 Nov 26;12(11):e228578. doi: 10.1136/bcr-2018-228578.
We report a case of a 73-year-old woman who developed pancreatic adenocarcinoma and presented with a colonic obstruction due to isolated metastasis to the colon, the primary lesion being diagnosed subsequently on imaging. The histopathological findings of the pancreatic mass exhibited a morphology and immunohistochemical profile consistent with a pancreatic adenocarcinoma and led to further analysis of the colonic pathology which ultimately confirmed the lesion was a pancreatic metastases rather than a primary colonic carcinoma. As the pancreatic cancer had metastasised to the colon, it was inoperable. The patient continued on palliative chemotherapy and passed 7 months after presentation for evaluation of her pancreatic mass due to progression of the pancreatic cancer. This report demonstrates a rare presentation of pancreatic cancer with colonic obstruction due to isolated metastatic disease and illustrated the importance of careful evaluation of histopathological findings.
我们报告一例73岁女性，其患胰腺腺癌并因孤立性转移至结肠而出现结肠梗阻，随后经影像学检查诊断出原发性病变。胰腺肿块的组织病理学检查结果显示出与胰腺腺癌一致的形态学和免疫组化特征，并促使对结肠病理进行进一步分析，最终证实该病变为胰腺转移瘤而非原发性结肠癌。由于胰腺癌已转移至结肠，故无法进行手术。患者继续接受姑息化疗，在因胰腺癌进展而就诊评估胰腺肿块7个月后去世。本报告展示了胰腺癌因孤立性转移疾病导致结肠梗阻的罕见表现，并说明了仔细评估组织病理学检查结果的重要性。
