Department of Clinical Laboratory, Shandong Provincial Hospital, Shandong University, Jinan, 250014, Shandong, China.
Adv Exp Med Biol. 2019;1206:179-198. doi: 10.1007/978-981-15-0602-4_9.
Living in a complex environment, humans are always faced with various external stimuli and internal changes including oxidative stress and tissue damage. To adapt to these stimuli, maintain physiological stability, and ensure survival, cells in the body initiate a series of interactive and regulatory response pathways. For example, increased reactive oxygen species in the body can induce autophagy through a variety of signalling pathways. This section will focus on ROS-mediated regulation of autophagy through PI3K/Akt, AMPK, JNK, ERK, ATG4, and other pathways.
生活在复杂的环境中，人类总是面临着各种外部刺激和内部变化，包括氧化应激和组织损伤。为了适应这些刺激，维持生理稳定性并确保生存，体内的细胞会启动一系列相互作用和调节反应途径。例如，体内活性氧的增加可以通过多种信号通路诱导自噬。本节将重点介绍 ROS 通过 PI3K/Akt、AMPK、JNK、ERK、ATG4 等途径介导的自噬调节。
