Hermansson A, Emgård P, Prellner K, Hellström S
Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
Am J Otolaryngol. 1988 May-Jun;9(3):97-101. doi: 10.1016/s0196-0709(88)80013-9.
The middle ears of 29 male Sprague-Dawley rats were injected with viable pneumococci, type 3 or 6A, and changes were monitored by otomicroscopy and analysis of bacterial samples from middle ear effusions, blood, and the nasopharynx. Depending on the type of pneumococci and its concentration, three responses were noted: otitis media with purulent effusion, otitis media with serous effusion, or no reaction. The mortality rate was low and the animals recovered without permanent deterioration or otomicroscopically discernable change. The results of this study show the rat to be a suitable animal model for the study of bacterial otitis media.
向29只雄性斯普拉格-道利大鼠的中耳注射3型或6A型活肺炎球菌，并通过耳显微镜检查以及对中耳积液、血液和鼻咽部细菌样本的分析来监测变化。根据肺炎球菌的类型及其浓度，观察到三种反应：脓性积液性中耳炎、浆液性积液性中耳炎或无反应。死亡率较低，动物恢复后未出现永久性恶化或耳显微镜下可辨别的变化。本研究结果表明，大鼠是研究细菌性中耳炎的合适动物模型。
